Stadium: Milam Stadium Round: 1
| NCAAF | 2019/10/19 20:00 | Harding Bisons v Southwestern Oklahoma State Bulldogs | L | 45-14 |
| NCAAF | 2018/10/13 19:00 | Southwestern Oklahoma State Bulldogs v Harding Bisons | L | 10-50 |
| NCAAF | 2021/10/30 22:30 | Southwestern Oklahoma State Bulldogs v Arkansas Tech Wonder Boys | L | 14-15 |
| NCAAF | 2021/10/23 19:00 | Southwestern Oklahoma State Bulldogs v East Central Tigers | L | 34-44 |
| NCAAF | 2021/10/14 23:00 | Southern Nazarene v Southwestern Oklahoma State Bulldogs | L | 30-22 |
| NCAAF | 2021/10/09 19:00 | Southwestern Oklahoma State Bulldogs v Ouachita Baptist Tigers | L | 10-30 |
| NCAAF | 2021/10/02 19:00 | Arkansas Monticello Boll Weevils v Southwestern Oklahoma State Bulldogs | L | 18-16 |
| NCAAF | 2021/09/25 23:00 | Southwestern Oklahoma State Bulldogs v Oklahoma Baptist Bison | L | 27-31 |
| NCAAF | 2021/09/18 23:00 | Southeastern Oklahoma State Savage Storm v Southwestern Oklahoma State Bulldogs | L | 37-28 |
| NCAAF | 2021/09/11 23:00 | Southern Arkansas Muleriders v Southwestern Oklahoma State Bulldogs | L | 42-27 |
| NCAAF | 2021/10/30 19:00 | Northwestern Oklahoma State Rangers v Harding Bisons | W | 14-73 |
| NCAAF | 2021/10/23 20:00 | Harding Bisons v Arkansas Monticello Boll Weevils | W | 64-7 |
| NCAAF | 2021/10/16 19:00 | Henderson State Reddies v Harding Bisons | W | 21-46 |
| NCAAF | 2021/10/09 19:00 | Harding Bisons v Southern Nazarene | W | 49-10 |
| NCAAF | 2021/10/02 19:00 | Oklahoma Baptist Bison v Harding Bisons | W | 7-31 |
| NCAAF | 2021/09/25 23:00 | Harding Bisons v Ouachita Baptist Tigers | W | 38-21 |
| NCAAF | 2021/09/18 23:00 | Southern Arkansas Muleriders v Harding Bisons | W | 6-37 |
| NCAAF | 2021/09/11 23:00 | Southeastern Oklahoma State Savage Storm v Harding Bisons | L | 32-31 |