Stadium: Wilkins Stadium Round: 1
| NCAAF | 2019/09/14 23:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | W | 30-28 |
| NCAAF | 2018/09/29 18:00 | Oklahoma Baptist Bison v Southern Arkansas Muleriders | W | 45-55 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2021/10/09 19:30 | Southern Arkansas Muleriders v Southeastern Oklahoma State Savage Storm | L | 24-38 |
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | L | 38-17 |
| NCAAF | 2021/09/25 23:00 | Henderson State Reddies v Southern Arkansas Muleriders | L | 56-49 |
| NCAAF | 2021/09/18 23:00 | Southern Arkansas Muleriders v Harding Bisons | L | 6-37 |
| NCAAF | 2021/09/11 23:00 | Southern Arkansas Muleriders v Southwestern Oklahoma State Bulldogs | W | 42-27 |
| NCAAF | 2021/09/02 23:00 | Northwestern Oklahoma State Rangers v Southern Arkansas Muleriders | W | 13-32 |
| NCAAF | 2021/10/23 23:00 | Oklahoma Baptist Bison v Southeastern Oklahoma State Savage Storm | W | 43-37 |
| NCAAF | 2021/10/16 23:00 | East Central Tigers v Oklahoma Baptist Bison | W | 20-47 |
| NCAAF | 2021/10/09 19:00 | Arkansas Tech Wonder Boys v Oklahoma Baptist Bison | L | 38-35 |
| NCAAF | 2021/10/02 19:00 | Oklahoma Baptist Bison v Harding Bisons | L | 7-31 |
| NCAAF | 2021/09/25 23:00 | Southwestern Oklahoma State Bulldogs v Oklahoma Baptist Bison | W | 27-31 |
| NCAAF | 2021/09/18 23:00 | Oklahoma Baptist Bison v Northwestern Oklahoma State Rangers | W | 56-42 |
| NCAAF | 2021/09/11 23:00 | Oklahoma Baptist Bison v Arkansas Monticello Boll Weevils | W | 45-20 |
| NCAAF | 2021/09/02 23:00 | Ouachita Baptist Tigers v Oklahoma Baptist Bison | L | 38-31 |