Stadium: SNU Stadium Round: 1
| NCAAF | 2019/09/05 22:00 | Southern Nazarene v Southern Arkansas Muleriders | L | 14-34 |
| NCAAF | 2018/10/06 19:00 | Southern Arkansas Muleriders v Southern Nazarene | L | 21-16 |
| NCAAF | 2021/10/30 19:00 | Henderson State Reddies v Southern Nazarene | L | 34-3 |
| NCAAF | 2021/10/23 20:00 | Northwestern Oklahoma State Rangers v Southern Nazarene | L | 47-27 |
| NCAAF | 2021/10/14 23:00 | Southern Nazarene v Southwestern Oklahoma State Bulldogs | W | 30-22 |
| NCAAF | 2021/10/09 19:00 | Harding Bisons v Southern Nazarene | L | 49-10 |
| NCAAF | 2021/10/02 18:00 | Southern Nazarene v Arkansas Tech Wonder Boys | L | 41-51 |
| NCAAF | 2021/09/25 19:00 | Southern Nazarene v Southeastern Oklahoma State Savage Storm | L | 10-31 |
| NCAAF | 2021/09/18 23:00 | East Central Tigers v Southern Nazarene | L | 40-13 |
| NCAAF | 2021/09/11 18:00 | Southern Nazarene v Ouachita Baptist Tigers | L | 3-41 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2021/10/09 19:30 | Southern Arkansas Muleriders v Southeastern Oklahoma State Savage Storm | L | 24-38 |
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | L | 38-17 |
| NCAAF | 2021/09/25 23:00 | Henderson State Reddies v Southern Arkansas Muleriders | L | 56-49 |
| NCAAF | 2021/09/18 23:00 | Southern Arkansas Muleriders v Harding Bisons | L | 6-37 |
| NCAAF | 2021/09/11 23:00 | Southern Arkansas Muleriders v Southwestern Oklahoma State Bulldogs | W | 42-27 |