Stadium: Meares Stadium Round: 1
| NCAAF | 2019/11/09 18:30 | Tusculum Pioneers v Mars Hill Lions | L | 24-7 |
| NCAAF | 2018/10/06 17:30 | Mars Hill Lions v Tusculum Pioneers | L | 28-31 |
| NCAAF | 2021/10/30 19:00 | Carson–Newman Eagles v Mars Hill Lions | W | 23-49 |
| NCAAF | 2021/10/23 17:00 | Mars Hill Lions v Catawba College | W | 31-14 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | W | 3-32 |
| NCAAF | 2021/10/09 17:30 | Mars Hill Lions v Barton Bulldogs | W | 40-32 |
| NCAAF | 2021/10/02 17:00 | Mars Hill Lions v Newberry Wolves | W | 28-22 |
| NCAAF | 2021/09/25 22:00 | Lenoir Rhyne Bears v Mars Hill Lions | L | 31-16 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | W | 44-9 |
| NCAAF | 2021/09/09 23:00 | Mars Hill Lions v Lynchburg Dragons | W | 50-14 |
| NCAAF | 2021/10/30 17:00 | Catawba College v Tusculum Pioneers | L | 31-28 |
| NCAAF | 2021/10/23 18:00 | Tusculum Pioneers v Barton Bulldogs | W | 41-17 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | W | 37-21 |
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 38-31 |
| NCAAF | 2021/10/02 22:00 | Wingate Bulldogs v Tusculum Pioneers | L | 43-35 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | L | 19-24 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | W | 24-21 |
| NCAAF | 2021/09/11 17:00 | Tusculum Pioneers v Chowan Hawks | L | 38-46 |