Stadium: Frank "Muddy" Waters Stadium Round: 1
| NCAAF | 2019/09/21 20:00 | Hillsdale Chargers v Lake Erie | W | 34-14 |
| NCAAF | 2018/09/22 20:00 | Hillsdale Chargers v Lake Erie | W | 41-7 |
| NCAAF | 2021/10/09 18:00 | Hillsdale Chargers v Walsh U. Cavaliers | W | 20-3 |
| NCAAF | 2021/10/02 20:00 | Tiffin Dragons v Hillsdale Chargers | W | 21-24 |
| NCAAF | 2021/09/25 20:00 | Hillsdale Chargers v Missouri S&t Miners | W | 38-31 |
| NCAAF | 2021/09/18 17:00 | Truman Bulldogs v Hillsdale Chargers | L | 38-24 |
| NCAAF | 2021/09/11 23:00 | Hillsdale Chargers v Indianapolis Greyhounds | L | 31-35 |
| NCAAF | 2021/09/04 18:00 | Michigan Technological University Huskies v Hillsdale Chargers | L | 14-10 |
| NCAAF | 2019/11/16 18:00 | Hillsdale Chargers v Ohio Dominican Panthers | L | 7-17 |
| NCAAF | 2019/11/09 18:00 | Tiffin Dragons v Hillsdale Chargers | L | 35-24 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | L | 20-28 |
| NCAAF | 2021/09/18 18:00 | Lake Erie v McKendree | W | 17-10 |
| NCAAF | 2021/09/11 17:00 | Franklin Pierce Ravens v Lake Erie | W | 20-31 |
| NCAAF | 2021/09/04 22:00 | Clarion Golden Eagles v Lake Erie | W | 26-31 |
| NCAAF | 2019/11/16 19:00 | Indianapolis Greyhounds v Lake Erie | L | 70-6 |
| NCAAF | 2019/11/09 18:00 | Ohio Dominican Panthers v Lake Erie | L | 49-10 |