Stadium: Frank "Muddy" Waters Stadium Round: 1
| NCAAF | 2019/11/16 18:00 | Hillsdale Chargers v Ohio Dominican Panthers | L | 7-17 |
| NCAAF | 2018/09/15 23:00 | Ohio Dominican Panthers v Hillsdale Chargers | W | 18-34 |
| NCAAF | 2021/11/06 17:00 | Hillsdale Chargers v Kentucky Wesleyan | W | 31-12 |
| NCAAF | 2021/10/30 17:00 | Ashland Eagles v Hillsdale Chargers | L | 28-17 |
| NCAAF | 2021/10/23 16:00 | Findlay Oilers v Hillsdale Chargers | W | 29-34 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | L | 14-33 |
| NCAAF | 2021/10/09 18:00 | Hillsdale Chargers v Walsh U. Cavaliers | W | 20-3 |
| NCAAF | 2021/10/02 20:00 | Tiffin Dragons v Hillsdale Chargers | W | 21-24 |
| NCAAF | 2021/09/25 20:00 | Hillsdale Chargers v Missouri S&t Miners | W | 38-31 |
| NCAAF | 2021/09/18 17:00 | Truman Bulldogs v Hillsdale Chargers | L | 38-24 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | W | 31-0 |
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 34-21 |
| NCAAF | 2021/10/23 16:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 56-17 |
| NCAAF | 2021/10/16 16:00 | Ohio Dominican Panthers v Findlay Oilers | L | 14-21 |
| NCAAF | 2021/10/09 23:00 | Ashland Eagles v Ohio Dominican Panthers | W | 24-34 |
| NCAAF | 2021/10/02 17:00 | Kentucky Wesleyan v Ohio Dominican Panthers | W | 30-32 |
| NCAAF | 2021/09/25 17:00 | Indianapolis Greyhounds v Ohio Dominican Panthers | W | 16-19 |
| NCAAF | 2021/09/18 17:00 | William Jewell College Cardinals v Ohio Dominican Panthers | W | 25-35 |