Stadium: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2019/09/28 18:00 | Lake Erie v Kentucky Wesleyan | W | 49-42 |
| NCAAF | 2018/10/20 18:00 | Kentucky Wesleyan v Lake Erie | L | 46-6 |
| NCAAF | 2021/10/23 17:00 | Ashland Eagles v Lake Erie | L | 42-41 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | L | 20-28 |
| NCAAF | 2021/09/18 18:00 | Lake Erie v McKendree | W | 17-10 |
| NCAAF | 2021/09/11 17:00 | Franklin Pierce Ravens v Lake Erie | W | 20-31 |
| NCAAF | 2021/09/04 22:00 | Clarion Golden Eagles v Lake Erie | W | 26-31 |
| NCAAF | 2021/10/23 16:00 | Kentucky Wesleyan v Tiffin Dragons | L | 28-34 |
| NCAAF | 2021/10/16 17:00 | Walsh U. Cavaliers v Kentucky Wesleyan | W | 13-23 |
| NCAAF | 2021/10/09 17:00 | Findlay Oilers v Kentucky Wesleyan | L | 31-19 |
| NCAAF | 2021/10/02 17:00 | Kentucky Wesleyan v Ohio Dominican Panthers | L | 30-32 |
| NCAAF | 2021/09/25 16:00 | Kentucky Wesleyan v William Jewell College Cardinals | W | 41-21 |
| NCAAF | 2021/09/19 00:00 | Kentucky Wesleyan v Lindenwood | L | 34-56 |
| NCAAF | 2021/09/11 17:00 | Kentucky Thorobreds v Kentucky Wesleyan | W | 25-26 |
| NCAAF | 2021/09/02 23:00 | Kentucky Wesleyan v Frostburg State | L | 13-20 |