Stadium: West Family Stadium Round: 1
| NCAAF | 2021/10/23 17:00 | Wheeling v West Liberty Hilltoppers | L | 26-20 |
| NCAAF | 2021/10/16 17:00 | West Liberty Hilltoppers v Fairmont State | W | 52-31 |
| NCAAF | 2021/10/09 17:00 | Concord University Mountain Lions v West Liberty Hilltoppers | L | 20-16 |
| NCAAF | 2021/10/02 17:00 | West Liberty Hilltoppers v Glenville State Pioneers | W | 20-19 |
| NCAAF | 2021/09/25 17:00 | W. Virginia Bobcats v West Liberty Hilltoppers | W | 0-31 |
| NCAAF | 2021/09/18 18:00 | West Liberty Hilltoppers v Notre Dame Falcons | L | 10-51 |
| NCAAF | 2021/09/11 17:00 | Alderson Broaddus Battlers v West Liberty Hilltoppers | W | 0-24 |
| NCAAF | 2021/09/02 23:00 | West Liberty Hilltoppers v Walsh U. Cavaliers | L | 6-27 |
| NCAAF | 2021/10/23 18:00 | Unc Pembroke Braves v University of Charleston Golden Eagles | W | 21-14 |
| NCAAF | 2021/10/16 22:00 | West Virginia State Yellow Jackets v Unc Pembroke Braves | W | 13-14 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling | W | 34-28 |
| NCAAF | 2021/10/02 17:00 | Frostburg State v Unc Pembroke Braves | L | 51-21 |
| NCAAF | 2021/09/25 17:00 | Unc Pembroke Braves v Fairmont State | L | 27-30 |
| NCAAF | 2021/09/18 22:00 | Unc Pembroke Braves v Glenville State Pioneers | W | 36-22 |
| NCAAF | 2021/09/11 16:00 | W. Virginia Bobcats v Unc Pembroke Braves | W | 0-1 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | W | 20-7 |