Stadium: Grace P. Johnson Stadium Round: 1
| NCAAF | 2021/10/30 16:00 | West Liberty Hilltoppers v Unc Pembroke Braves | W | 17-27 |
| NCAAF | 2021/10/23 18:00 | Unc Pembroke Braves v University of Charleston Golden Eagles | W | 21-14 |
| NCAAF | 2021/10/16 22:00 | West Virginia State Yellow Jackets v Unc Pembroke Braves | W | 13-14 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling | W | 34-28 |
| NCAAF | 2021/10/02 17:00 | Frostburg State v Unc Pembroke Braves | L | 51-21 |
| NCAAF | 2021/09/25 17:00 | Unc Pembroke Braves v Fairmont State | L | 27-30 |
| NCAAF | 2021/09/18 22:00 | Unc Pembroke Braves v Glenville State Pioneers | W | 36-22 |
| NCAAF | 2021/09/11 16:00 | W. Virginia Bobcats v Unc Pembroke Braves | W | 0-1 |
| NCAAF | 2021/10/30 16:00 | Notre Dame Falcons v Fairmont State | W | 45-0 |
| NCAAF | 2021/10/23 17:30 | Glenville State Pioneers v Notre Dame Falcons | W | 14-34 |
| NCAAF | 2021/10/16 17:00 | Notre Dame Falcons v W. Virginia Bobcats | W | 52-14 |
| NCAAF | 2021/10/09 16:00 | Notre Dame Falcons v Frostburg State | W | 23-21 |
| NCAAF | 2021/10/02 16:00 | University of Charleston Golden Eagles v Notre Dame Falcons | L | 38-28 |
| NCAAF | 2021/09/25 16:00 | Notre Dame Falcons v West Virginia State Yellow Jackets | W | 38-14 |
| NCAAF | 2021/09/18 18:00 | West Liberty Hilltoppers v Notre Dame Falcons | W | 10-51 |
| NCAAF | 2021/09/09 23:00 | Wheeling v Notre Dame Falcons | W | 15-31 |