Stadium: James LaRosa Athletic Field Round: 1
| NCAAF | 2021/10/16 18:00 | Frostburg State v Wheeling Jesuit | L | 41-17 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling Jesuit | L | 34-28 |
| NCAAF | 2021/10/02 18:00 | Wheeling Jesuit v W. Virginia Bobcats | W | 38-0 |
| NCAAF | 2021/09/25 16:00 | Glenville State Pioneers v Wheeling Jesuit | W | 10-27 |
| NCAAF | 2021/09/18 17:00 | Wheeling Jesuit v Alderson Broaddus Battlers | W | 28-6 |
| NCAAF | 2021/09/09 23:00 | Wheeling Jesuit v Notre Dame Falcons | L | 15-31 |
| NCAAF | 2021/09/02 23:00 | Seton Hill Griffins v Wheeling Jesuit | L | 16-14 |
| NCAAF | 2019/11/16 17:00 | Concord University Mountain Lions v Wheeling Jesuit | W | 20-27 |
| NCAAF | 2021/10/16 17:00 | West Liberty Hilltoppers v Fairmont State | W | 52-31 |
| NCAAF | 2021/10/09 17:00 | Concord University Mountain Lions v West Liberty Hilltoppers | L | 20-16 |
| NCAAF | 2021/10/02 17:00 | West Liberty Hilltoppers v Glenville State Pioneers | W | 20-19 |
| NCAAF | 2021/09/25 17:00 | W. Virginia Bobcats v West Liberty Hilltoppers | W | 0-31 |
| NCAAF | 2021/09/18 18:00 | West Liberty Hilltoppers v Notre Dame Falcons | L | 10-51 |
| NCAAF | 2021/09/11 17:00 | Alderson Broaddus Battlers v West Liberty Hilltoppers | W | 0-24 |
| NCAAF | 2021/09/02 23:00 | West Liberty Hilltoppers v Walsh U. Cavaliers | L | 6-27 |
| NCAAF | 2019/11/16 18:00 | West Liberty Hilltoppers v University of Charleston Golden Eagles | L | 26-34 |