Stadium: University of Charleston Stadium Round: 1
| NCAAF | 2021/10/28 23:00 | University of Charleston Golden Eagles v W. Virginia Bobcats | W | 45-6 |
| NCAAF | 2021/10/23 18:00 | Unc Pembroke Braves v University of Charleston Golden Eagles | L | 21-14 |
| NCAAF | 2021/10/16 16:00 | University of Charleston Golden Eagles v Concord University Mountain Lions | W | 48-3 |
| NCAAF | 2021/10/09 17:00 | Glenville State Pioneers v University of Charleston Golden Eagles | W | 9-20 |
| NCAAF | 2021/10/02 16:00 | University of Charleston Golden Eagles v Notre Dame Falcons | W | 38-28 |
| NCAAF | 2021/09/25 17:00 | Alderson Broaddus Battlers v University of Charleston Golden Eagles | W | 7-69 |
| NCAAF | 2021/09/18 17:00 | Frostburg State v University of Charleston Golden Eagles | L | 30-24 |
| NCAAF | 2021/09/09 23:00 | University of Charleston Golden Eagles v Fairmont State | W | 27-6 |
| NCAAF | 2021/10/30 16:00 | Wheeling v Concord University Mountain Lions | W | 15-14 |
| NCAAF | 2021/10/23 17:00 | Wheeling v West Liberty Hilltoppers | W | 26-20 |
| NCAAF | 2021/10/16 18:00 | Frostburg State v Wheeling | L | 41-17 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling | L | 34-28 |
| NCAAF | 2021/10/02 18:00 | Wheeling v W. Virginia Bobcats | W | 38-0 |
| NCAAF | 2021/09/25 16:00 | Glenville State Pioneers v Wheeling | W | 10-27 |
| NCAAF | 2021/09/18 17:00 | Wheeling v Alderson Broaddus Battlers | W | 28-6 |
| NCAAF | 2021/09/09 23:00 | Wheeling v Notre Dame Falcons | L | 15-31 |