Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 |
| NCAAF | 2019/11/09 16:00 | Virginia Wise Highland Cavaliers v Catawba College | W | 21-14 |
| NCAAF | 2019/11/02 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 |
| NCAAF | 2019/10/26 22:00 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-13 |
| NCAAF | 2019/10/19 17:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 19-21 |
| NCAAF | 2021/09/18 17:00 | Carson–Newman Eagles v Wingate Bulldogs | L | 3-25 |
| NCAAF | 2021/09/02 23:00 | Carson–Newman Eagles v West Georgia | L | 7-45 |
| NCAAF | 2019/11/30 19:00 | Lenoir Rhyne Bears v Carson–Newman Eagles | L | 49-21 |
| NCAAF | 2019/11/23 18:00 | Bowie State Bulldogs v Carson–Newman Eagles | W | 9-17 |
| NCAAF | 2019/11/16 18:00 | Carson–Newman Eagles v Tusculum Pioneers | W | 49-13 |
| NCAAF | 2019/11/09 18:00 | Limestone Saints v Carson–Newman Eagles | W | 35-42 |
| NCAAF | 2019/11/02 17:00 | Mars Hill Lions v Carson–Newman Eagles | W | 21-48 |
| NCAAF | 2019/10/26 19:00 | Carson–Newman Eagles v Newberry Wolves | W | 24-21 |