Stadium: Shuford Stadium Round: 1
| NCAAF | 2021/10/30 17:00 | Catawba College v Tusculum Pioneers | W | 31-28 |
| NCAAF | 2021/10/23 17:00 | Mars Hill Lions v Catawba College | L | 31-14 |
| NCAAF | 2021/10/16 21:00 | Newberry Wolves v Catawba College | L | 14-7 |
| NCAAF | 2021/10/09 17:00 | Catawba College v Carson–Newman Eagles | W | 33-27 |
| NCAAF | 2021/09/18 17:00 | Catawba College v Barton Bulldogs | W | 17-10 |
| NCAAF | 2021/09/11 23:00 | Catawba College v Winston-Salem State | W | 28-6 |
| NCAAF | 2021/09/04 17:00 | Catawba College v Erskine Flying Fleet | W | 37-27 |
| NCAAF | 2019/11/16 17:00 | Catawba College v Lenoir Rhyne Bears | L | 3-49 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |
| NCAAF | 2021/10/23 16:00 | Virginia Wise Highland Cavaliers v Wingate Bulldogs | L | 21-48 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | L | 37-21 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | L | 14-37 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |