Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 |
| NCAAF | 2019/11/09 16:00 | Virginia Wise Highland Cavaliers v Catawba College | W | 21-14 |
| NCAAF | 2019/11/02 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 |
| NCAAF | 2019/10/26 22:00 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-13 |
| NCAAF | 2021/09/25 22:00 | Lenoir Rhyne Bears v Mars Hill Lions | W | 31-16 |
| NCAAF | 2021/09/18 22:00 | Newberry Wolves v Lenoir Rhyne Bears | L | 28-21 |
| NCAAF | 2021/09/04 22:00 | Virginia State Trojans v Lenoir Rhyne Bears | W | 7-48 |
| NCAAF | 2019/12/07 18:00 | Lenoir Rhyne Bears v West Florida | L | 38-43 |
| NCAAF | 2019/11/30 19:00 | Lenoir Rhyne Bears v Carson–Newman Eagles | W | 49-21 |
| NCAAF | 2019/11/23 19:00 | Lenoir Rhyne Bears v Miles Golden Bears | W | 36-7 |
| NCAAF | 2019/11/16 17:00 | Catawba College v Lenoir Rhyne Bears | W | 3-49 |
| NCAAF | 2019/11/09 19:00 | Lenoir Rhyne Bears v Unc Pembroke Braves | W | 45-31 |