Stadium: Gaffney High School Reservation Stadium Round: 1
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | L | 45-3 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | L | 3-32 |
| NCAAF | 2021/10/09 17:00 | Limestone Saints v Wingate Bulldogs | L | 17-35 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | L | 7-45 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | L | 24-21 |
| NCAAF | 2021/09/04 23:00 | North Greenville Crusaders v Limestone Saints | L | 37-16 |
| NCAAF | 2019/11/16 18:00 | Newberry Wolves v Limestone Saints | L | 14-7 |
| NCAAF | 2019/11/09 18:00 | Limestone Saints v Carson–Newman Eagles | L | 35-42 |
| NCAAF | 2021/10/23 16:00 | Virginia Wise Highland Cavaliers v Wingate Bulldogs | L | 21-48 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | L | 37-21 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | L | 14-37 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |