Stadium: Gaffney High School Reservation Stadium Round: 1
| NCAAF | 2019/11/16 18:00 | Newberry Wolves v Limestone Saints | L | 14-7 |
| NCAAF | 2018/10/20 17:00 | Limestone Saints v Newberry Wolves | L | 13-29 |
| NCAAF | 2021/11/06 17:00 | Carson–Newman Eagles v Limestone Saints | L | 27-21 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 24-28 |
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | L | 45-3 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | L | 3-32 |
| NCAAF | 2021/10/09 17:00 | Limestone Saints v Wingate Bulldogs | L | 17-35 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | L | 7-45 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | L | 24-21 |
| NCAAF | 2021/09/04 23:00 | North Greenville Crusaders v Limestone Saints | L | 37-16 |
| NCAAF | 2021/11/06 17:00 | Newberry Wolves v Wingate Bulldogs | W | 41-35 |
| NCAAF | 2021/10/30 17:00 | Erskine Flying Fleet v Newberry Wolves | W | 10-48 |
| NCAAF | 2021/10/23 20:00 | Newberry Wolves v Carson–Newman Eagles | W | 34-3 |
| NCAAF | 2021/10/16 21:00 | Newberry Wolves v Catawba College | W | 14-7 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | W | 14-37 |
| NCAAF | 2021/10/02 17:00 | Mars Hill Lions v Newberry Wolves | L | 28-22 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | W | 19-24 |
| NCAAF | 2021/09/18 22:00 | Newberry Wolves v Lenoir Rhyne Bears | W | 28-21 |