Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 |
| NCAAF | 2019/11/09 16:00 | Virginia Wise Highland Cavaliers v Catawba College | W | 21-14 |
| NCAAF | 2019/11/02 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 |
| NCAAF | 2021/10/02 17:00 | Mars Hill Lions v Newberry Wolves | L | 28-22 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | W | 19-24 |
| NCAAF | 2021/09/18 22:00 | Newberry Wolves v Lenoir Rhyne Bears | W | 28-21 |
| NCAAF | 2021/09/11 22:00 | Newberry Wolves v North Greenville Crusaders | L | 14-24 |
| NCAAF | 2021/09/04 18:00 | Barton Bulldogs v Newberry Wolves | W | 7-31 |
| NCAAF | 2019/11/16 18:00 | Newberry Wolves v Limestone Saints | W | 14-7 |
| NCAAF | 2019/11/09 23:00 | Wingate Bulldogs v Newberry Wolves | L | 35-28 |
| NCAAF | 2019/11/02 17:00 | Newberry Wolves v Unc Pembroke Braves | W | 37-34 |