Stadium: Pioneer Field Round: 1
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 38-31 |
| NCAAF | 2021/10/02 22:00 | Wingate Bulldogs v Tusculum Pioneers | L | 43-35 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | L | 19-24 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | W | 24-21 |
| NCAAF | 2021/09/11 17:00 | Tusculum Pioneers v Chowan Hawks | L | 38-46 |
| NCAAF | 2021/09/04 17:00 | St Augustines Falcons v Tusculum Pioneers | W | 14-58 |
| NCAAF | 2019/11/16 18:00 | Carson–Newman Eagles v Tusculum Pioneers | L | 49-13 |
| NCAAF | 2019/11/09 18:30 | Tusculum Pioneers v Mars Hill Lions | W | 24-7 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | L | 14-37 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/09/11 23:30 | East Tennessee State v Virginia Wise Highland Cavaliers | L | 45-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | W | 54-0 |
| NCAAF | 2019/11/16 18:00 | Unc Pembroke Braves v Virginia Wise Highland Cavaliers | L | 20-7 |
| NCAAF | 2019/11/09 16:00 | Virginia Wise Highland Cavaliers v Catawba College | W | 21-14 |