Stadium: William H. Greene Stadium Round: 1
| NCAAF | 2021/10/23 19:00 | Truman Bulldogs v William Jewell College Cardinals | L | 52-0 |
| NCAAF | 2021/10/16 18:00 | Missouri S&t Miners v William Jewell College Cardinals | L | 37-16 |
| NCAAF | 2021/10/09 20:00 | William Jewell College Cardinals v Southwest Baptist University Bearcats | L | 10-55 |
| NCAAF | 2021/10/02 18:00 | McKendree v William Jewell College Cardinals | L | 52-10 |
| NCAAF | 2021/09/25 16:00 | Kentucky Wesleyan v William Jewell College Cardinals | L | 41-21 |
| NCAAF | 2021/09/18 17:00 | William Jewell College Cardinals v Ohio Dominican Panthers | L | 25-35 |
| NCAAF | 2021/09/11 18:00 | William Jewell College Cardinals v Black Hills State | L | 21-31 |
| NCAAF | 2021/09/03 00:00 | Colorado Mesa University Mavericks v William Jewell College Cardinals | L | 40-3 |
| NCAAF | 2021/10/23 18:00 | Lindenwood v Southwest Baptist University Bearcats | W | 48-24 |
| NCAAF | 2021/10/16 22:00 | Indianapolis Greyhounds v Lindenwood | W | 20-28 |
| NCAAF | 2021/10/09 18:00 | Lindenwood v Quincy | W | 33-28 |
| NCAAF | 2021/10/02 23:00 | Truman Bulldogs v Lindenwood | W | 21-31 |
| NCAAF | 2021/09/25 16:00 | Findlay Oilers v Lindenwood | W | 16-28 |
| NCAAF | 2021/09/19 00:00 | Kentucky Wesleyan v Lindenwood | W | 34-56 |
| NCAAF | 2021/09/11 23:00 | South Dakota State v Lindenwood | L | 52-7 |
| NCAAF | 2021/09/03 00:00 | Lindenwood v Angelo State Univeristy Rams | L | 20-40 |