Stadium: Harlen C. Hunter Stadium Round: 1
| NCAAF | 2021/11/06 18:00 | Missouri S&t Miners v Lindenwood | W | 16-43 |
| NCAAF | 2021/10/30 18:00 | William Jewell College Cardinals v Lindenwood | W | 10-53 |
| NCAAF | 2021/10/23 18:00 | Lindenwood v Southwest Baptist University Bearcats | W | 48-24 |
| NCAAF | 2021/10/16 22:00 | Indianapolis Greyhounds v Lindenwood | W | 20-28 |
| NCAAF | 2021/10/09 18:00 | Lindenwood v Quincy | W | 33-28 |
| NCAAF | 2021/10/02 23:00 | Truman Bulldogs v Lindenwood | W | 21-31 |
| NCAAF | 2021/09/25 16:00 | Findlay Oilers v Lindenwood | W | 16-28 |
| NCAAF | 2021/09/19 00:00 | Kentucky Wesleyan v Lindenwood | W | 34-56 |
| NCAAF | 2021/11/06 18:00 | McKendree v Truman Bulldogs | L | 13-44 |
| NCAAF | 2021/10/30 18:00 | Southwest Baptist University Bearcats v McKendree | W | 42-45 |
| NCAAF | 2021/10/23 18:00 | McKendree v Missouri S&t Miners | L | 31-37 |
| NCAAF | 2021/10/16 20:00 | Quincy v McKendree | W | 48-51 |
| NCAAF | 2021/10/09 22:00 | Indianapolis Greyhounds v McKendree | L | 57-28 |
| NCAAF | 2021/10/02 18:00 | McKendree v William Jewell College Cardinals | W | 52-10 |
| NCAAF | 2021/09/25 18:00 | Walsh U. Cavaliers v McKendree | W | 10-24 |
| NCAAF | 2021/09/18 18:00 | Lake Erie v McKendree | L | 17-10 |