Stadium: Eiler-Martin Stadium Round: 1
| NCAAF | 2021/11/06 16:00 | Shepherd Rams v East Stroudsburg Warriors | L | 55-7 |
| NCAAF | 2021/10/30 17:05 | East Stroudsburg Warriors v Shippensburg Raiders | L | 23-24 |
| NCAAF | 2021/10/23 17:00 | East Stroudsburg Warriors v Bloomsburg Huskies | W | 35-14 |
| NCAAF | 2021/10/16 16:00 | West Chester Golden Rams v East Stroudsburg Warriors | L | 42-24 |
| NCAAF | 2021/10/09 18:05 | East Stroudsburg Warriors v Millersville University of Pennsylvania Marauders | W | 27-7 |
| NCAAF | 2021/10/02 16:05 | Kutztown Golden Bears v East Stroudsburg Warriors | L | 21-14 |
| NCAAF | 2021/09/25 22:00 | Lock Haven v East Stroudsburg Warriors | W | 21-45 |
| NCAAF | 2021/09/18 17:05 | East Stroudsburg Warriors v Mercyhurst | W | 17-7 |
| NCAAF | 2021/11/06 16:00 | Mercyhurst v Gannon University Golden Knights | L | 24-13 |
| NCAAF | 2021/10/30 16:00 | Gannon University Golden Knights v Slippery Rock | L | 21-63 |
| NCAAF | 2021/10/23 16:00 | Gannon University Golden Knights v Edinboro | W | 21-18 |
| NCAAF | 2021/10/16 20:00 | Seton Hill Griffins v Gannon University Golden Knights | W | 10-14 |
| NCAAF | 2021/10/09 16:00 | Gannon University Golden Knights v California Vulcans | L | 17-38 |
| NCAAF | 2021/10/02 18:00 | Iup Crimson Hawks v Gannon University Golden Knights | L | 28-23 |
| NCAAF | 2021/09/25 17:00 | Gannon University Golden Knights v Clarion Golden Eagles | W | 56-21 |
| NCAAF | 2021/09/18 18:00 | Bloomsburg Huskies v Gannon University Golden Knights | L | 31-27 |