Stadium: Panther Stadium Round: 1
| NCAAF | 2019/11/09 18:00 | Ohio Dominican Panthers v Lake Erie | W | 49-10 |
| NCAAF | 2018/11/10 17:00 | Lake Erie v Ohio Dominican Panthers | W | 6-62 |
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 34-21 |
| NCAAF | 2021/10/23 16:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 56-17 |
| NCAAF | 2021/10/16 16:00 | Ohio Dominican Panthers v Findlay Oilers | L | 14-21 |
| NCAAF | 2021/10/09 23:00 | Ashland Eagles v Ohio Dominican Panthers | W | 24-34 |
| NCAAF | 2021/10/02 17:00 | Kentucky Wesleyan v Ohio Dominican Panthers | W | 30-32 |
| NCAAF | 2021/09/25 17:00 | Indianapolis Greyhounds v Ohio Dominican Panthers | W | 16-19 |
| NCAAF | 2021/09/18 17:00 | William Jewell College Cardinals v Ohio Dominican Panthers | W | 25-35 |
| NCAAF | 2021/09/11 17:00 | Ohio Dominican Panthers v Virginia State Trojans | W | 10-7 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | W | 38-28 |
| NCAAF | 2021/10/23 17:00 | Ashland Eagles v Lake Erie | L | 42-41 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | L | 20-28 |
| NCAAF | 2021/09/18 18:00 | Lake Erie v McKendree | W | 17-10 |
| NCAAF | 2021/09/11 17:00 | Franklin Pierce Ravens v Lake Erie | W | 20-31 |