Stadium: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2019/10/05 19:00 | Lake Erie v Walsh U. Cavaliers | L | 6-21 |
| NCAAF | 2018/10/13 23:00 | Lake Erie v Walsh U. Cavaliers | L | 0-29 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | W | 38-28 |
| NCAAF | 2021/10/23 17:00 | Ashland Eagles v Lake Erie | L | 42-41 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | L | 20-28 |
| NCAAF | 2021/09/18 18:00 | Lake Erie v McKendree | W | 17-10 |
| NCAAF | 2021/11/06 16:00 | Walsh U. Cavaliers v Tiffin Dragons | L | 16-56 |
| NCAAF | 2021/10/30 16:00 | Walsh U. Cavaliers v Findlay Oilers | L | 0-49 |
| NCAAF | 2021/10/23 16:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | L | 56-17 |
| NCAAF | 2021/10/16 17:00 | Walsh U. Cavaliers v Kentucky Wesleyan | L | 13-23 |
| NCAAF | 2021/10/09 18:00 | Hillsdale Chargers v Walsh U. Cavaliers | L | 20-3 |
| NCAAF | 2021/09/30 23:00 | Walsh U. Cavaliers v Ashland Eagles | L | 10-35 |
| NCAAF | 2021/09/25 18:00 | Walsh U. Cavaliers v McKendree | L | 10-24 |
| NCAAF | 2021/09/18 18:00 | Quincy v Walsh U. Cavaliers | L | 38-17 |