Stadium: Memorial Stadium/Bob Cunningham Field Round: 1
| NCAAF | 2019/11/16 19:00 | Wayne State Wildcats v Sioux Falls Cougars | L | 21-41 |
| NCAAF | 2018/11/10 19:00 | Sioux Falls Cougars v Wayne State Wildcats | L | 26-7 |
| NCAAF | 2021/10/30 17:00 | Upper Iowa v Wayne State Wildcats | L | 42-41 |
| NCAAF | 2021/10/23 22:00 | Southwest Minnesota State Mustangs v Wayne State Wildcats | W | 16-38 |
| NCAAF | 2021/10/16 18:00 | Wayne State Wildcats v Augustana Vikings | L | 24-32 |
| NCAAF | 2021/10/09 18:00 | Minnesota State Mankato Mavericks v Wayne State Wildcats | W | 24-35 |
| NCAAF | 2021/10/02 18:00 | Wayne State Wildcats v Winona State Warriors | W | 38-21 |
| NCAAF | 2021/09/25 23:00 | Minnesota Duluth Bulldogs v Wayne State Wildcats | W | 28-31 |
| NCAAF | 2021/09/18 23:00 | Wayne State Wildcats v Minot State Beavers | W | 48-0 |
| NCAAF | 2021/09/11 19:00 | Bemidji State Beavers v Wayne State Wildcats | L | 38-28 |
| NCAAF | 2021/10/30 18:00 | Minnesota State Mankato Mavericks v Sioux Falls Cougars | W | 35-45 |
| NCAAF | 2021/10/23 18:00 | Sioux Falls Cougars v Winona State Warriors | L | 10-14 |
| NCAAF | 2021/10/16 18:00 | Sioux Falls Cougars v University of Mary Marauders | W | 34-14 |
| NCAAF | 2021/10/09 22:00 | Southwest Minnesota State Mustangs v Sioux Falls Cougars | W | 7-35 |
| NCAAF | 2021/10/02 18:00 | Sioux Falls Cougars v Augustana Vikings | W | 28-26 |
| NCAAF | 2021/09/25 23:00 | Northern State Wolves v Sioux Falls Cougars | L | 41-10 |
| NCAAF | 2021/09/18 18:00 | Sioux Falls Cougars v Concordia University Golden Bears | W | 50-14 |
| NCAAF | 2021/09/11 18:00 | Minot State Beavers v Sioux Falls Cougars | W | 10-49 |