Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2019/10/05 19:00 | Missouri Southern Lions v Central Missouri Mules | L | 42-71 |
| NCAAF | 2018/09/29 18:00 | Central Missouri Mules v Missouri Southern Lions | L | 61-7 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | W | 32-52 |
| NCAAF | 2021/10/02 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 16-20 |
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Central Oklahoma v Missouri Southern Lions | W | 10-14 |
| NCAAF | 2021/09/11 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | L | 17-21 |
| NCAAF | 2021/09/03 00:00 | Nebraska Kearney v Missouri Southern Lions | L | 38-0 |
| NCAAF | 2019/11/16 19:00 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 65-6 |
| NCAAF | 2019/11/09 21:00 | Missouri Southern Lions v Emporia State | L | 6-29 |
| NCAAF | 2021/10/09 18:00 | Central Missouri Mules v Emporia State | W | 45-38 |
| NCAAF | 2021/10/02 19:00 | Northeastern State Riverhawks v Central Missouri Mules | W | 10-41 |
| NCAAF | 2021/09/25 18:00 | Central Missouri Mules v Nebraska Kearney | L | 28-31 |
| NCAAF | 2021/09/18 18:00 | Central Missouri Mules v NW Missouri State | L | 7-47 |
| NCAAF | 2021/09/09 23:00 | Washburn Ichabods Football v Central Missouri Mules | L | 29-10 |
| NCAAF | 2021/09/03 00:00 | Central Missouri Mules v Pittsburgh State Gorillas | L | 16-35 |
| NCAAF | 2019/11/30 18:00 | Ferris State v Central Missouri Mules | L | 37-10 |
| NCAAF | 2019/11/23 19:00 | Central Missouri Mules v Indianapolis Greyhounds | W | 37-27 |