Stadium: Dwight T. Reed Stadium Round: 1
| NCAAF | 2021/10/23 19:00 | Nebraska Kearney v Blue Tigers | L | 56-0 |
| NCAAF | 2021/10/16 18:00 | Pittsburgh State Gorillas v Blue Tigers | L | 59-7 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | L | 32-52 |
| NCAAF | 2021/10/02 19:00 | Central Oklahoma v Blue Tigers | L | 69-28 |
| NCAAF | 2021/09/25 18:00 | Blue Tigers v Northeastern State Riverhawks | L | 48-49 |
| NCAAF | 2021/09/19 00:00 | Fort Hays State University Tigers v Blue Tigers | L | 72-0 |
| NCAAF | 2021/09/02 23:00 | Blue Tigers v Washburn Ichabods Football | L | 12-76 |
| NCAAF | 2021/02/20 00:00 | Nicholls State v Blue Tigers | L | 87-3 |
| NCAAF | 2021/10/23 18:30 | Central Missouri Mules v Fort Hays State University Tigers | L | 17-21 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | L | 30-28 |
| NCAAF | 2021/10/09 18:00 | Central Missouri Mules v Emporia State | W | 45-38 |
| NCAAF | 2021/10/02 19:00 | Northeastern State Riverhawks v Central Missouri Mules | W | 10-41 |
| NCAAF | 2021/09/25 18:00 | Central Missouri Mules v Nebraska Kearney | L | 28-31 |
| NCAAF | 2021/09/18 18:00 | Central Missouri Mules v NW Missouri State | L | 7-47 |
| NCAAF | 2021/09/09 23:00 | Washburn Ichabods Football v Central Missouri Mules | L | 29-10 |
| NCAAF | 2021/09/03 00:00 | Central Missouri Mules v Pittsburgh State Gorillas | L | 16-35 |