Stadium: Kimbrough Memorial Stadium Round: 1
| NCAAF | 2019/11/16 20:00 | West Texas AM Buffaloes v Midwestern State University Mustangs | W | 34-24 |
| NCAAF | 2018/11/10 19:00 | Midwestern State University Mustangs v West Texas AM Buffaloes | L | 24-23 |
| NCAAF | 2021/10/31 00:00 | Texas AM Kingsville Javelinas v West Texas AM Buffaloes | W | 23-35 |
| NCAAF | 2021/10/23 23:00 | West Texas AM Buffaloes v East Texas A&M | L | 3-15 |
| NCAAF | 2021/10/17 00:00 | Eastern New Mexico University Greyhounds v West Texas AM Buffaloes | W | 24-44 |
| NCAAF | 2021/10/10 00:00 | West Texas AM Buffaloes v Angelo State Univeristy Rams | W | 31-15 |
| NCAAF | 2021/10/02 20:05 | Western Oregon v West Texas AM Buffaloes | L | 41-38 |
| NCAAF | 2021/09/26 00:00 | West Texas AM Buffaloes v Colorado School of Mines | L | 13-21 |
| NCAAF | 2021/09/19 00:00 | West Texas AM Buffaloes v Western New Mexico Mustangs | W | 42-14 |
| NCAAF | 2021/09/11 23:00 | Texas-Permian Basin Falcons v West Texas AM Buffaloes | L | 42-31 |
| NCAAF | 2021/10/31 00:00 | Midwestern State University Mustangs v Western New Mexico Mustangs | W | 52-10 |
| NCAAF | 2021/10/23 23:00 | Tarleton State v Midwestern State University Mustangs | L | 17-14 |
| NCAAF | 2021/10/10 00:00 | Midwestern State University Mustangs v Texas AM Kingsville Javelinas | W | 30-13 |
| NCAAF | 2021/10/03 01:00 | Central Washington v Midwestern State University Mustangs | L | 30-20 |
| NCAAF | 2021/09/26 00:00 | Midwestern State University Mustangs v Eastern New Mexico University Greyhounds | W | 31-24 |
| NCAAF | 2021/09/18 23:00 | Angelo State Univeristy Rams v Midwestern State University Mustangs | W | 17-35 |
| NCAAF | 2021/09/11 23:00 | Midwestern State University Mustangs v East Texas A&M | W | 31-30 |
| NCAAF | 2021/09/04 18:00 | Quincy v Midwestern State University Mustangs | W | 27-48 |