Stadium: Burke-Tarr Stadium Round: 1
| NCAAF | 2019/11/09 18:00 | Limestone Saints v Carson–Newman Eagles | W | 35-42 |
| NCAAF | 2018/10/06 17:00 | Carson–Newman Eagles v Limestone Saints | W | 52-24 |
| NCAAF | 2021/10/30 19:00 | Carson–Newman Eagles v Mars Hill Lions | L | 23-49 |
| NCAAF | 2021/10/23 20:00 | Newberry Wolves v Carson–Newman Eagles | L | 34-3 |
| NCAAF | 2021/10/16 17:00 | Carson–Newman Eagles v Lenoir Rhyne Bears | L | 0-59 |
| NCAAF | 2021/10/09 17:00 | Catawba College v Carson–Newman Eagles | L | 33-27 |
| NCAAF | 2021/10/02 18:00 | Barton Bulldogs v Carson–Newman Eagles | L | 31-17 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | L | 33-7 |
| NCAAF | 2021/09/18 17:00 | Carson–Newman Eagles v Wingate Bulldogs | L | 3-25 |
| NCAAF | 2021/09/02 23:00 | Carson–Newman Eagles v West Georgia | L | 7-45 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 24-28 |
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | L | 45-3 |
| NCAAF | 2021/10/16 20:00 | Limestone Saints v Mars Hill Lions | L | 3-32 |
| NCAAF | 2021/10/09 17:00 | Limestone Saints v Wingate Bulldogs | L | 17-35 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | L | 7-45 |
| NCAAF | 2021/09/18 17:30 | Tusculum Pioneers v Limestone Saints | L | 24-21 |
| NCAAF | 2021/09/04 23:00 | North Greenville Crusaders v Limestone Saints | L | 37-16 |
| NCAAF | 2019/11/16 18:00 | Newberry Wolves v Limestone Saints | L | 14-7 |