Stadium: Chryst Field at Biemesderfer Stadium Round: 1
| NCAAF | 2021/11/06 16:00 | Millersville University of Pennsylvania Marauders v Bloomsburg Huskies | L | 35-38 |
| NCAAF | 2021/10/30 18:05 | Kutztown Golden Bears v Millersville University of Pennsylvania Marauders | L | 30-7 |
| NCAAF | 2021/10/23 17:00 | Shippensburg Raiders v Millersville University of Pennsylvania Marauders | L | 38-7 |
| NCAAF | 2021/10/16 18:00 | Millersville University of Pennsylvania Marauders v Shepherd Rams | L | 13-38 |
| NCAAF | 2021/10/09 18:05 | East Stroudsburg Warriors v Millersville University of Pennsylvania Marauders | L | 27-7 |
| NCAAF | 2021/10/02 16:00 | Millersville University of Pennsylvania Marauders v Lock Haven | W | 31-29 |
| NCAAF | 2021/09/25 20:00 | Millersville University of Pennsylvania Marauders v West Chester Golden Rams | L | 14-42 |
| NCAAF | 2021/09/18 17:00 | California Vulcans v Millersville University of Pennsylvania Marauders | L | 30-0 |
| NCAAF | 2021/11/06 16:00 | Edinboro v Clarion Golden Eagles | W | 17-10 |
| NCAAF | 2021/10/30 18:00 | Iup Crimson Hawks v Edinboro | W | 17-21 |
| NCAAF | 2021/10/23 16:00 | Gannon University Golden Knights v Edinboro | L | 21-18 |
| NCAAF | 2021/10/16 16:00 | Edinboro v Mercyhurst | L | 20-27 |
| NCAAF | 2021/10/09 18:00 | Edinboro v Slippery Rock | L | 13-49 |
| NCAAF | 2021/10/02 20:00 | Seton Hill Griffins v Edinboro | W | 7-17 |
| NCAAF | 2021/09/25 16:00 | Edinboro v California Vulcans | L | 12-20 |
| NCAAF | 2021/09/18 16:00 | West Chester Golden Rams v Edinboro | L | 41-37 |