Stadium: Seth Grove Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Shippensburg Raiders v Lock Haven | W | 52-14 |
| NCAAF | 2021/10/30 17:05 | East Stroudsburg Warriors v Shippensburg Raiders | W | 23-24 |
| NCAAF | 2021/10/23 17:00 | Shippensburg Raiders v Millersville University of Pennsylvania Marauders | W | 38-7 |
| NCAAF | 2021/10/16 21:00 | Kutztown Golden Bears v Shippensburg Raiders | L | 20-3 |
| NCAAF | 2021/10/09 17:00 | Shippensburg Raiders v West Chester Golden Rams | W | 34-18 |
| NCAAF | 2021/10/02 16:00 | Shepherd Rams v Shippensburg Raiders | L | 59-27 |
| NCAAF | 2021/09/25 17:00 | Shippensburg Raiders v Bloomsburg Huskies | W | 51-7 |
| NCAAF | 2021/09/18 17:00 | Clarion Golden Eagles v Shippensburg Raiders | W | 33-62 |
| NCAAF | 2021/11/06 16:00 | Mercyhurst v Gannon University Golden Knights | W | 24-13 |
| NCAAF | 2021/10/30 16:00 | Clarion Golden Eagles v Mercyhurst | W | 20-38 |
| NCAAF | 2021/10/23 16:00 | Mercyhurst v Slippery Rock | L | 17-20 |
| NCAAF | 2021/10/16 16:00 | Edinboro v Mercyhurst | W | 20-27 |
| NCAAF | 2021/10/09 16:00 | Mercyhurst v Seton Hill Griffins | L | 17-19 |
| NCAAF | 2021/10/02 19:00 | California Vulcans v Mercyhurst | L | 37-0 |
| NCAAF | 2021/09/25 17:00 | Mercyhurst v Iup Crimson Hawks | L | 13-48 |
| NCAAF | 2021/09/18 17:05 | East Stroudsburg Warriors v Mercyhurst | L | 17-7 |