Stadium: Scheels Field at MSUM Football Stadium Round: 1
| NCAAF | 2018/10/13 18:00 | Wayne State Wildcats v Minnesota State University Moorhead Dragons | W | 22-28 |
| NCAAF | 2021/11/06 17:00 | Concordia University Golden Bears v Minnesota State University Moorhead Dragons | W | 3-24 |
| NCAAF | 2021/10/30 17:00 | Minnesota State University Moorhead Dragons v Northern State Wolves | L | 27-33 |
| NCAAF | 2021/10/23 17:00 | Minnesota State University Moorhead Dragons v University of Mary Marauders | W | 35-31 |
| NCAAF | 2021/10/16 18:00 | Bemidji State Beavers v Minnesota State University Moorhead Dragons | L | 22-19 |
| NCAAF | 2021/10/09 19:00 | Minot State Beavers v Minnesota State University Moorhead Dragons | W | 17-29 |
| NCAAF | 2021/10/02 17:00 | Minnesota State University Moorhead Dragons v Minnesota Duluth Bulldogs | L | 21-26 |
| NCAAF | 2021/09/25 17:00 | Minnesota State University Moorhead Dragons v Upper Iowa | W | 33-28 |
| NCAAF | 2021/09/18 18:00 | Augustana Vikings v Minnesota State University Moorhead Dragons | L | 43-17 |
| NCAAF | 2021/11/06 18:00 | Wayne State Wildcats v Sioux Falls Cougars | L | 17-38 |
| NCAAF | 2021/10/30 17:00 | Upper Iowa v Wayne State Wildcats | L | 42-41 |
| NCAAF | 2021/10/23 22:00 | Southwest Minnesota State Mustangs v Wayne State Wildcats | W | 16-38 |
| NCAAF | 2021/10/16 18:00 | Wayne State Wildcats v Augustana Vikings | L | 24-32 |
| NCAAF | 2021/10/09 18:00 | Minnesota State Mankato Mavericks v Wayne State Wildcats | W | 24-35 |
| NCAAF | 2021/10/02 18:00 | Wayne State Wildcats v Winona State Warriors | W | 38-21 |
| NCAAF | 2021/09/25 23:00 | Minnesota Duluth Bulldogs v Wayne State Wildcats | W | 28-31 |
| NCAAF | 2021/09/18 23:00 | Wayne State Wildcats v Minot State Beavers | W | 48-0 |