Stadium: Dwight T. Reed Stadium Round: 1
| NCAAF | 2021/10/02 19:00 | Central Oklahoma v Blue Tigers | L | 69-28 |
| NCAAF | 2021/09/25 18:00 | Blue Tigers v Northeastern State Riverhawks | L | 48-49 |
| NCAAF | 2021/09/19 00:00 | Fort Hays State University Tigers v Blue Tigers | L | 72-0 |
| NCAAF | 2021/09/02 23:00 | Blue Tigers v Washburn Ichabods Football | L | 12-76 |
| NCAAF | 2021/02/20 00:00 | Nicholls State v Blue Tigers | L | 87-3 |
| NCAAF | 2019/11/16 18:00 | Blue Tigers v Missouri Western Griffons | L | 8-71 |
| NCAAF | 2019/11/09 19:00 | Central Missouri Mules v Blue Tigers | L | 73-6 |
| NCAAF | 2019/11/02 18:00 | Blue Tigers v Fort Hays State University Tigers | L | 6-66 |
| NCAAF | 2021/10/02 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 16-20 |
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Central Oklahoma v Missouri Southern Lions | W | 10-14 |
| NCAAF | 2021/09/11 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | L | 17-21 |
| NCAAF | 2021/09/03 00:00 | Nebraska Kearney v Missouri Southern Lions | L | 38-0 |
| NCAAF | 2019/11/16 19:00 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 65-6 |
| NCAAF | 2019/11/09 21:00 | Missouri Southern Lions v Emporia State | L | 6-29 |
| NCAAF | 2019/11/02 18:00 | Central Oklahoma v Missouri Southern Lions | L | 52-27 |