Stadium: Dwight T. Reed Stadium Round: 1
| NCAAF | 2021/11/06 18:00 | Emporia State v Blue Tigers | L | 56-21 |
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | L | 35-77 |
| NCAAF | 2021/10/23 19:00 | Nebraska Kearney v Blue Tigers | L | 56-0 |
| NCAAF | 2021/10/16 18:00 | Pittsburgh State Gorillas v Blue Tigers | L | 59-7 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | L | 32-52 |
| NCAAF | 2021/10/02 19:00 | Central Oklahoma v Blue Tigers | L | 69-28 |
| NCAAF | 2021/09/25 18:00 | Blue Tigers v Northeastern State Riverhawks | L | 48-49 |
| NCAAF | 2021/09/19 00:00 | Fort Hays State University Tigers v Blue Tigers | L | 72-0 |
| NCAAF | 2021/11/06 18:00 | Missouri Western Griffons v Central Missouri Mules | W | 59-28 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | W | 28-45 |
| NCAAF | 2021/10/23 21:00 | Missouri Western Griffons v Pittsburgh State Gorillas | L | 14-34 |
| NCAAF | 2021/10/16 21:00 | Missouri Western Griffons v Northeastern State Riverhawks | W | 57-24 |
| NCAAF | 2021/10/09 19:00 | Nebraska Kearney v Missouri Western Griffons | L | 35-14 |
| NCAAF | 2021/10/02 23:00 | Missouri Western Griffons v NW Missouri State | L | 7-30 |
| NCAAF | 2021/09/25 18:00 | Washburn Ichabods Football v Missouri Western Griffons | L | 47-41 |
| NCAAF | 2021/09/18 23:00 | Missouri Western Griffons v Emporia State | W | 38-37 |