Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2019/10/12 21:00 | Missouri Western Griffons v Missouri Southern Lions | L | 43-34 |
| NCAAF | 2018/10/06 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 10-33 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | L | 24-21 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | W | 30-28 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | W | 32-52 |
| NCAAF | 2021/10/02 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 16-20 |
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Central Oklahoma v Missouri Southern Lions | W | 10-14 |
| NCAAF | 2021/09/11 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | L | 17-21 |
| NCAAF | 2021/09/03 00:00 | Nebraska Kearney v Missouri Southern Lions | L | 38-0 |
| NCAAF | 2021/10/23 21:00 | Missouri Western Griffons v Pittsburgh State Gorillas | L | 14-34 |
| NCAAF | 2021/10/16 21:00 | Missouri Western Griffons v Northeastern State Riverhawks | W | 57-24 |
| NCAAF | 2021/10/09 19:00 | Nebraska Kearney v Missouri Western Griffons | L | 35-14 |
| NCAAF | 2021/10/02 23:00 | Missouri Western Griffons v NW Missouri State | L | 7-30 |
| NCAAF | 2021/09/25 18:00 | Washburn Ichabods Football v Missouri Western Griffons | L | 47-41 |
| NCAAF | 2021/09/18 23:00 | Missouri Western Griffons v Emporia State | W | 38-37 |
| NCAAF | 2021/09/10 00:00 | Missouri Western Griffons v Fort Hays State University Tigers | W | 38-31 |
| NCAAF | 2021/09/03 00:00 | Central Oklahoma v Missouri Western Griffons | L | 24-20 |