Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2019/09/21 23:00 | Missouri Southern Lions v NW Missouri State | L | 34-66 |
| NCAAF | 2018/09/15 18:30 | NW Missouri State v Missouri Southern Lions | L | 63-0 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | L | 24-21 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | W | 30-28 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | W | 32-52 |
| NCAAF | 2021/10/02 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 16-20 |
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Central Oklahoma v Missouri Southern Lions | W | 10-14 |
| NCAAF | 2021/09/11 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | L | 17-21 |
| NCAAF | 2021/10/30 19:00 | NW Missouri State v Nebraska Kearney | W | 66-13 |
| NCAAF | 2021/10/23 18:00 | Northeastern State Riverhawks v NW Missouri State | W | 7-59 |
| NCAAF | 2021/10/16 18:00 | Washburn Ichabods Football v NW Missouri State | L | 17-16 |
| NCAAF | 2021/10/09 18:30 | NW Missouri State v Pittsburgh State Gorillas | W | 20-19 |
| NCAAF | 2021/10/02 23:00 | Missouri Western Griffons v NW Missouri State | W | 7-30 |
| NCAAF | 2021/09/25 18:30 | NW Missouri State v Central Oklahoma | W | 38-0 |
| NCAAF | 2021/09/18 18:00 | Central Missouri Mules v NW Missouri State | W | 7-47 |
| NCAAF | 2021/09/03 00:00 | Fort Hays State University Tigers v NW Missouri State | W | 7-15 |