Stadium: Bobcat Stadium Round: 1
| NCAAF | 2021/10/30 17:00 | Alderson Broaddus Battlers v Frostburg State | W | 7-45 |
| NCAAF | 2021/10/23 17:00 | Fairmont State v Frostburg State | W | 14-49 |
| NCAAF | 2021/10/16 18:00 | Frostburg State v Wheeling Jesuit | W | 41-17 |
| NCAAF | 2021/10/09 16:00 | Notre Dame Falcons v Frostburg State | L | 23-21 |
| NCAAF | 2021/10/02 17:00 | Frostburg State v Unc Pembroke Braves | W | 51-21 |
| NCAAF | 2021/09/25 17:00 | Concord University Mountain Lions v Frostburg State | W | 23-42 |
| NCAAF | 2021/09/18 17:00 | Frostburg State v University of Charleston Golden Eagles | W | 30-24 |
| NCAAF | 2021/09/11 16:00 | West Virginia State Yellow Jackets v Frostburg State | W | 21-34 |
| NCAAF | 2021/10/28 23:00 | University of Charleston Golden Eagles v W. Virginia Bobcats | L | 45-6 |
| NCAAF | 2021/10/23 17:00 | W. Virginia Bobcats v Alderson Broaddus Battlers | L | 20-49 |
| NCAAF | 2021/10/16 17:00 | Notre Dame Falcons v W. Virginia Bobcats | L | 52-14 |
| NCAAF | 2021/10/09 17:30 | W. Virginia Bobcats v West Virginia State Yellow Jackets | L | 3-38 |
| NCAAF | 2021/10/02 18:00 | Wheeling Jesuit v W. Virginia Bobcats | L | 38-0 |
| NCAAF | 2021/09/25 17:00 | W. Virginia Bobcats v West Liberty Hilltoppers | L | 0-31 |
| NCAAF | 2021/09/18 18:00 | Concord University Mountain Lions v W. Virginia Bobcats | L | 28-25 |
| NCAAF | 2021/09/11 16:00 | W. Virginia Bobcats v Unc Pembroke Braves | L | 0-1 |