Stadium: Macon Centreplex
| SPHL | 2021/10/15 23:35 | Knoxville Ice Bears v Macon Mayhem | L | 3-1 |
| SPHL | 2021/04/30 23:30 | Macon Mayhem v Knoxville Ice Bears | W | 4-1 |
| SPHL | 2021/04/20 23:35 | Knoxville Ice Bears v Macon Mayhem | L | 3-0 |
| SPHL | 2021/04/13 23:35 | Knoxville Ice Bears v Macon Mayhem | W | 1-2 |
| SPHL | 2021/04/02 23:35 | Knoxville Ice Bears v Macon Mayhem | L | 4-2 |
| SPHL | 2021/03/21 20:00 | Macon Mayhem v Knoxville Ice Bears | W | 4-1 |
| SPHL | 2021/03/07 20:00 | Knoxville Ice Bears v Macon Mayhem | L | 4-0 |
| SPHL | 2021/02/21 21:00 | Macon Mayhem v Knoxville Ice Bears | W | 2-1 |
| SPHL | 2021/11/06 00:00 | Huntsville Havoc v Macon Mayhem | L | 6-1 |
| SPHL | 2021/10/30 22:00 | Fayetteville Marksmen v Macon Mayhem | L | 2-1 |
| SPHL | 2021/10/29 23:30 | Macon Mayhem v Fayetteville Marksmen | L | 3-4 |
| SPHL | 2021/10/24 00:15 | Peoria Rivermen v Macon Mayhem | L | 3-2 |
| SPHL | 2021/10/23 00:15 | Peoria Rivermen v Macon Mayhem | L | 6-0 |
| SPHL | 2021/10/15 23:35 | Knoxville Ice Bears v Macon Mayhem | L | 3-1 |
| SPHL | 2021/05/15 22:30 | Macon Mayhem v Pensacola Ice Flyers | L | 1-4 |
| SPHL | 2021/05/15 00:05 | Pensacola Ice Flyers v Macon Mayhem | L | 4-2 |
| SPHL | 2021/11/13 01:00 | Evansville Thunderbolts v Knoxville Ice Bears | W | 1-4 |
| SPHL | 2021/11/11 01:00 | Huntsville Havoc v Knoxville Ice Bears | L | 6-5 |
| SPHL | 2021/11/07 20:00 | Fayetteville Marksmen v Knoxville Ice Bears | L | 3-1 |
| SPHL | 2021/11/06 22:00 | Fayetteville Marksmen v Knoxville Ice Bears | W | 1-3 |
| SPHL | 2021/11/05 23:35 | Knoxville Ice Bears v Fayetteville Marksmen | W | 3-2 |
| SPHL | 2021/10/31 19:00 | Knoxville Ice Bears v Huntsville Havoc | L | 0-2 |
| SPHL | 2021/10/30 23:35 | Knoxville Ice Bears v Roanoke Rail Yard Dawgs | W | 3-2 |
| SPHL | 2021/10/23 00:00 | Birmingham Bulls v Knoxville Ice Bears | W | 2-3 |