Stadium: Knoxville Civic Auditorium and Coliseum
| SPHL | 2021/11/13 23:30 | Macon Mayhem v Knoxville Ice Bears | W | 0-9 |
| SPHL | 2021/10/15 23:35 | Knoxville Ice Bears v Macon Mayhem | W | 3-1 |
| SPHL | 2021/04/30 23:30 | Macon Mayhem v Knoxville Ice Bears | L | 4-1 |
| SPHL | 2021/04/20 23:35 | Knoxville Ice Bears v Macon Mayhem | W | 3-0 |
| SPHL | 2021/04/13 23:35 | Knoxville Ice Bears v Macon Mayhem | L | 1-2 |
| SPHL | 2021/04/02 23:35 | Knoxville Ice Bears v Macon Mayhem | W | 4-2 |
| SPHL | 2021/03/21 20:00 | Macon Mayhem v Knoxville Ice Bears | L | 4-1 |
| SPHL | 2021/03/07 20:00 | Knoxville Ice Bears v Macon Mayhem | W | 4-0 |
| SPHL | 2021/12/12 01:15 | Peoria Rivermen v Knoxville Ice Bears | L | 5-4 |
| SPHL | 2021/12/11 01:15 | Peoria Rivermen v Knoxville Ice Bears | L | 5-4 |
| SPHL | 2021/12/05 20:00 | Fayetteville Marksmen v Knoxville Ice Bears | W | 0-3 |
| SPHL | 2021/12/04 01:00 | Birmingham Bulls v Knoxville Ice Bears | W | 4-6 |
| SPHL | 2021/11/27 00:35 | Knoxville Ice Bears v Birmingham Bulls | W | 2-0 |
| SPHL | 2021/11/25 00:35 | Knoxville Ice Bears v Birmingham Bulls | W | 5-0 |
| SPHL | 2021/11/21 01:00 | Vermilion County Bobcats v Knoxville Ice Bears | W | 2-3 |
| SPHL | 2021/11/20 00:35 | Knoxville Ice Bears v Vermilion County Bobcats | W | 9-3 |
| SPHL | 2021/12/17 00:30 | Macon Mayhem v Fayetteville Marksmen | L | 2-5 |
| SPHL | 2021/12/11 23:30 | Macon Mayhem v Roanoke Rail Yard Dawgs | W | 4-2 |
| SPHL | 2021/12/11 00:30 | Macon Mayhem v Roanoke Rail Yard Dawgs | L | 0-3 |
| SPHL | 2021/12/04 23:30 | Macon Mayhem v Pensacola Ice Flyers | L | 0-4 |
| SPHL | 2021/12/04 01:05 | Pensacola Ice Flyers v Macon Mayhem | L | 7-1 |
| SPHL | 2021/12/03 01:00 | Birmingham Bulls v Macon Mayhem | W | 0-3 |
| SPHL | 2021/11/27 23:30 | Macon Mayhem v Evansville Thunderbolts | W | 3-2 |
| SPHL | 2021/11/27 00:30 | Macon Mayhem v Evansville Thunderbolts | L | 0-3 |