| Nicaragua Segunda Division | 2021/08/22 21:00 | Real Granada FC v Deportivo Masaya | W | 0-1 |
| Nicaragua Segunda Division | 2021/05/01 21:00 | Deportivo Masaya v San Judas | D | 1-1 |
| Nicaragua Segunda Division | 2021/04/28 17:00 | San Judas v Deportivo Masaya | D | 0-0 |
| Nicaragua Segunda Division | 2021/04/14 21:00 | San Marcos FC v Deportivo Masaya | W | 1-2 |
| Nicaragua Segunda Division | 2021/03/28 20:00 | Deportivo Masaya v Real Granada FC | W | 7-1 |
| Nicaragua Segunda Division | 2021/03/21 21:00 | Deportivo Masaya v Genesis Rivas | W | 12-0 |
| Nicaragua Segunda Division | 2021/03/17 21:00 | Organica Masachapa FC v Deportivo Masaya | W | 1-2 |
| Nicaragua Segunda Division | 2021/02/28 21:00 | Deportivo Masaya v Genesis Rivas | D | 1-1 |
| Nicaragua Segunda Division | 2021/08/15 21:00 | San Judas v America JDE | W | 2-3 |
| Nicaragua Segunda Division | 2021/08/07 21:30 | America JDE v Organica Masachapa FC | L | 0-1 |
| Nicaragua Segunda Division | 2021/05/10 20:30 | America JDE v HYH Export Sebaco FC | D | 1-1 |
| Nicaragua Segunda Division | 2021/05/07 19:00 | HYH Export Sebaco FC v America JDE | L | 2-0 |
| Nicaragua Segunda Division | 2021/05/02 21:00 | America JDE v Rancho Santana FC | W | 4-0 |
| Nicaragua Segunda Division | 2021/04/21 21:00 | America JDE v UNAN Managua | W | 4-0 |
| Nicaragua Segunda Division | 2021/04/14 21:30 | Real Xolotlan v America JDE | W | 1-3 |
| Nicaragua Segunda Division | 2021/03/28 20:00 | America JDE v CS Municipal | W | 1-0 |