[2] Inter Milan 2-0 Shakhtar Donetsk [4] 2021-11-24 17:45
Stadium: Giuseppe Meazza Round: 5
Referee: Ovidiu Alin Hategan Home Manager: Simone Inzaghi Away Manager: Roberto De Zerbi
Head to Head
| UEFA Champions League | 2021/09/28 16:45 | Shakhtar Donetsk v Inter Milan | D | 0-0 |
| UEFA Champions League | 2020/12/09 20:00 | Inter Milan v Shakhtar Donetsk | D | 0-0 |
| UEFA Champions League | 2020/10/27 17:55 | Shakhtar Donetsk v Inter Milan | D | 0-0 |
| UEFA Europa League | 2020/08/17 19:00 | Inter Milan v Shakhtar Donetsk | W | 5-0 |
Home History
| Italy Serie A | 2021/11/21 17:00 | Inter Milan v Napoli | W | 3-2 |
| Italy Serie A | 2021/11/07 19:45 | AC Milan v Inter Milan | D | 1-1 |
| UEFA Champions League | 2021/11/03 20:00 | Sheriff Tiraspol v Inter Milan | W | 1-3 |
| Italy Serie A | 2021/10/31 11:30 | Inter Milan v Udinese | W | 2-0 |
| Italy Serie A | 2021/10/27 18:45 | Empoli v Inter Milan | W | 0-2 |
| Italy Serie A | 2021/10/24 18:45 | Inter Milan v Juventus | D | 1-1 |
| UEFA Champions League | 2021/10/19 19:00 | Inter Milan v Sheriff Tiraspol | W | 3-1 |
| Italy Serie A | 2021/10/16 16:00 | Lazio v Inter Milan | L | 3-1 |
Away History
| Ukraine Vyscha Liga | 2021/11/20 15:00 | Shakhtar Donetsk v FC Rukh Lviv | W | 2-0 |
| Ukraine Vyscha Liga | 2021/11/07 15:00 | Kolos Kovalivka v Shakhtar Donetsk | W | 1-3 |
| UEFA Champions League | 2021/11/03 17:45 | Real Madrid v Shakhtar Donetsk | L | 2-1 |
| Ukraine Vyscha Liga | 2021/10/30 14:00 | Shakhtar Donetsk v Desna Chernihiv | W | 4-1 |
| Ukraine Cup | 2021/10/27 16:30 | Chernomorets Odessa v Shakhtar Donetsk | W | 0-3 |
| Ukraine Vyscha Liga | 2021/10/23 14:00 | Vorskla Poltava v Shakhtar Donetsk | W | 0-2 |
| UEFA Champions League | 2021/10/19 19:00 | Shakhtar Donetsk v Real Madrid | L | 0-5 |
| Ukraine Vyscha Liga | 2021/10/15 14:00 | Shakhtar Donetsk v FC Zorya Lugansk | W | 6-1 |