[1] Real Madrid 2-1 Shakhtar Donetsk [4] 2021-11-03 17:45
Stadium: Santiago Bernabeu Round: 4
Referee: Benoit Bastien Home Manager: Carlo Ancelotti Away Manager: Roberto De Zerbi
Head to Head
| UEFA Champions League | 2021/10/19 19:00 | Shakhtar Donetsk v Real Madrid | W | 0-5 |
| UEFA Champions League | 2020/12/01 17:55 | Shakhtar Donetsk v Real Madrid | L | 2-0 |
| UEFA Champions League | 2020/10/21 16:55 | Real Madrid v Shakhtar Donetsk | L | 2-3 |
| UEFA Champions League | 2015/11/25 19:45 | Shakhtar Donetsk v Real Madrid | W | 3-4 |
| UEFA Champions League | 2015/09/15 18:45 | Real Madrid v Shakhtar Donetsk | W | 4-0 |
Home History
| Spain La Liga | 2021/10/30 12:00 | Elche v Real Madrid | W | 1-2 |
| Spain La Liga | 2021/10/27 19:30 | Real Madrid v Osasuna | D | 0-0 |
| Spain La Liga | 2021/10/24 14:15 | Barcelona v Real Madrid | W | 1-2 |
| UEFA Champions League | 2021/10/19 19:00 | Shakhtar Donetsk v Real Madrid | W | 0-5 |
| Spain La Liga | 2021/10/03 14:15 | Espanyol v Real Madrid | L | 2-1 |
| UEFA Champions League | 2021/09/28 19:00 | Real Madrid v Sheriff Tiraspol | L | 1-2 |
| Spain La Liga | 2021/09/25 19:00 | Real Madrid v Villarreal | D | 0-0 |
| Spain La Liga | 2021/09/22 20:00 | Real Madrid v Mallorca | W | 6-1 |
Away History
| Ukraine Vyscha Liga | 2021/10/30 14:00 | Shakhtar Donetsk v Desna Chernihiv | W | 4-1 |
| Ukraine Cup | 2021/10/27 16:30 | Chernomorets Odessa v Shakhtar Donetsk | W | 0-3 |
| Ukraine Vyscha Liga | 2021/10/23 14:00 | Vorskla Poltava v Shakhtar Donetsk | W | 0-2 |
| UEFA Champions League | 2021/10/19 19:00 | Shakhtar Donetsk v Real Madrid | L | 0-5 |
| Ukraine Vyscha Liga | 2021/10/15 14:00 | Shakhtar Donetsk v FC Zorya Lugansk | W | 6-1 |
| Ukraine Vyscha Liga | 2021/10/03 16:30 | Dynamo Kiev v Shakhtar Donetsk | D | 0-0 |
| UEFA Champions League | 2021/09/28 16:45 | Shakhtar Donetsk v Inter Milan | D | 0-0 |
| Ukraine Vyscha Liga | 2021/09/25 14:00 | Shakhtar Donetsk v FC Veres Rivne | W | 4-1 |