[2] Napoli 2-3 Spartak Moscow [4] 2021-09-30 16:45
Stadium: Stadio Diego Armando Maradona Round: 2
Referee: Ivan Kruzliak Home Manager: Luciano Spalletti Away Manager: Rui Vitoria
Home History
| Italy Serie A | 2021/09/26 18:45 | Napoli v Cagliari | W | 2-0 |
| Italy Serie A | 2021/09/23 16:30 | Sampdoria v Napoli | W | 0-4 |
| Italy Serie A | 2021/09/20 18:45 | Udinese v Napoli | W | 0-4 |
| UEFA Europa League | 2021/09/16 19:00 | Leicester v Napoli | D | 2-2 |
| Italy Serie A | 2021/09/11 16:00 | Napoli v Juventus | W | 2-1 |
| Elite Club Friendlies | 2021/09/06 19:00 | Napoli v Benevento | L | 1-5 |
| Italy Serie A | 2021/08/29 16:30 | Genoa v Napoli | W | 1-2 |
| Italy Serie A | 2021/08/22 18:45 | Napoli v Venezia | W | 2-0 |
Away History
| Russia Premier League | 2021/09/25 16:00 | Spartak Moscow v FC Ufa | W | 2-0 |
| Russia Premier League | 2021/09/20 16:30 | CSKA Moscow v Spartak Moscow | L | 1-0 |
| UEFA Europa League | 2021/09/15 14:30 | Spartak Moscow v Legia Warsaw | L | 0-1 |
| Russia Premier League | 2021/09/11 16:00 | Spartak Moscow v FK Khimki | W | 3-1 |
| Russia Premier League | 2021/08/26 15:30 | Spartak Moscow v PFC Sochi | L | 1-2 |
| Russia Premier League | 2021/08/21 13:00 | Arsenal Tula v Spartak Moscow | D | 1-1 |
| Russia Premier League | 2021/08/14 14:30 | Spartak Moscow v Ural | W | 1-0 |
| UEFA Champions League Qualifying | 2021/08/10 19:00 | Benfica v Spartak Moscow | L | 2-0 |