[1] Lyon 3-0 Sparta Prague [2] 2021-11-04 17:45
Stadium: Groupama Stadium Round: 4
Referee: Maurizio Mariani Home Manager: Peter Bosz Away Manager: Pavel Vrba
Head to Head
| UEFA Europa League | 2021/10/21 19:00 | Sparta Prague v Lyon | W | 3-4 |
Home History
| France Ligue 1 | 2021/10/30 19:00 | Lyon v Lens | W | 2-1 |
| France Ligue 1 | 2021/10/24 11:00 | Nice v Lyon | L | 3-2 |
| UEFA Europa League | 2021/10/21 19:00 | Sparta Prague v Lyon | W | 3-4 |
| France Ligue 1 | 2021/10/16 19:00 | Lyon v Monaco | W | 2-0 |
| France Ligue 1 | 2021/10/03 18:45 | St Etienne v Lyon | D | 1-1 |
| UEFA Europa League | 2021/09/30 16:45 | Lyon v Brondby | W | 3-0 |
| France Ligue 1 | 2021/09/25 19:00 | Lyon v Lorient | D | 1-1 |
| France Ligue 1 | 2021/09/22 19:00 | Lyon v Troyes | W | 3-1 |
Away History
| Czechia First League | 2021/10/31 14:00 | Banik Ostrava v Sparta Prague | D | 2-2 |
| Czech Republic Cup | 2021/10/27 15:00 | FK Teplice v Sparta Prague | W | 0-2 |
| Czechia First League | 2021/10/24 17:00 | Sparta Prague v Mlada Boleslav | W | 1-0 |
| UEFA Europa League | 2021/10/21 19:00 | Sparta Prague v Lyon | L | 3-4 |
| Czechia First League | 2021/10/17 17:00 | Pardubice v Sparta Prague | W | 2-4 |
| Czechia First League | 2021/10/03 17:00 | Sparta Prague v Slavia Prague | W | 1-0 |
| UEFA Europa League | 2021/09/30 16:45 | Sparta Prague v Rangers | W | 1-0 |
| Czechia First League | 2021/09/25 17:00 | FC Trinity Zlin v Sparta Prague | W | 2-5 |