| Nicaragua Segunda Division | 2021/08/25 21:00 | Organica Masachapa FC v Real Granada FC | D | 1-1 |
| Nicaragua Segunda Division | 2021/08/22 21:00 | Real Granada FC v Deportivo Masaya | L | 0-1 |
| Nicaragua Segunda Division | 2021/05/08 21:00 | Real Granada FC v Atlético Somotillo | D | 3-3 |
| Nicaragua Segunda Division | 2021/04/21 21:00 | San Marcos FC v Real Granada FC | D | 2-2 |
| Nicaragua Segunda Division | 2021/04/07 21:00 | Real Granada FC v Rancho Santana FC | W | 3-2 |
| Nicaragua Segunda Division | 2021/03/28 20:00 | Deportivo Masaya v Real Granada FC | L | 7-1 |
| Nicaragua Segunda Division | 2021/03/24 21:00 | Real Granada FC v Organica Masachapa FC | D | 4-4 |
| Nicaragua Segunda Division | 2021/03/20 21:00 | Real Granada FC v San Marcos FC | W | 4-1 |
| Nicaragua Segunda Division | 2021/08/25 21:00 | Deportivo Masaya v America JDE | W | 0-1 |
| Nicaragua Segunda Division | 2021/08/15 21:00 | San Judas v America JDE | W | 2-3 |
| Nicaragua Segunda Division | 2021/08/07 21:30 | America JDE v Organica Masachapa FC | L | 0-1 |
| Nicaragua Segunda Division | 2021/05/10 20:30 | America JDE v HYH Export Sebaco FC | D | 1-1 |
| Nicaragua Segunda Division | 2021/05/07 19:00 | HYH Export Sebaco FC v America JDE | L | 2-0 |
| Nicaragua Segunda Division | 2021/05/02 21:00 | America JDE v Rancho Santana FC | W | 4-0 |
| Nicaragua Segunda Division | 2021/04/21 21:00 | America JDE v UNAN Managua | W | 4-0 |
| Nicaragua Segunda Division | 2021/04/14 21:30 | Real Xolotlan v America JDE | W | 1-3 |