Stadium: Torero Stadium Round: 1
Home Manager: Dale Lindsey Away Manager: Landon Fox
| NCAAF | 2021/04/17 17:00 | San Diego v Valparaiso | W | 19-20 |
| NCAAF | 2019/10/19 21:00 | Valparaiso v San Diego | L | 17-42 |
| NCAAF | 2021/10/23 17:00 | Dayton v Valparaiso | W | 28-45 |
| NCAAF | 2021/10/09 18:00 | Valparaiso v St.Thomas MIN | L | 13-20 |
| NCAAF | 2021/10/02 17:00 | Marist v Valparaiso | L | 27-24 |
| NCAAF | 2021/09/25 17:00 | Valparaiso v Drake Bulldogs | W | 24-21 |
| NCAAF | 2021/09/18 18:00 | Dartmouth v Valparaiso | L | 28-18 |
| NCAAF | 2021/09/11 19:30 | Valparaiso v North Dakota State | L | 0-64 |
| NCAAF | 2021/09/04 22:00 | Indiana Wesleyan Wildcats v Valparaiso | L | 28-10 |
| NCAAF | 2021/04/17 17:00 | San Diego v Valparaiso | W | 19-20 |
| NCAAF | 2021/10/23 17:00 | San Diego v Presbyterian | W | 69-28 |
| NCAAF | 2021/10/16 21:00 | Drake Bulldogs v San Diego | W | 10-13 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler | W | 52-21 |
| NCAAF | 2021/10/02 20:00 | St.Thomas MIN v San Diego | W | 24-27 |
| NCAAF | 2021/09/25 16:00 | San Diego v Davidson Wildcats | L | 16-28 |
| NCAAF | 2021/09/18 19:00 | San Diego v Montana State | L | 10-52 |
| NCAAF | 2021/09/11 20:00 | UC Davis v San Diego | L | 53-7 |
| NCAAF | 2021/09/04 20:00 | Cal Poly v San Diego | L | 28-17 |