San Diego 69-28 Presbyterian 2021-10-23 17:00
Stadium: Bailey Memorial Stadium Round: 1
Home History
| NCAAF | 2021/10/16 21:00 | Drake Bulldogs v San Diego | W | 10-13 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler | W | 52-21 |
| NCAAF | 2021/10/02 20:00 | St. Thomas (MN) v San Diego | W | 24-27 |
| NCAAF | 2021/09/25 16:00 | San Diego v Davidson Wildcats | L | 16-28 |
| NCAAF | 2021/09/18 19:00 | San Diego v Montana State | L | 10-52 |
| NCAAF | 2021/09/11 20:00 | UC Davis v San Diego | L | 53-7 |
| NCAAF | 2021/09/04 20:00 | Cal Poly v San Diego | L | 28-17 |
| NCAAF | 2021/04/17 17:00 | San Diego v Valparaiso | L | 19-20 |
Away History
| NCAAF | 2021/10/16 23:00 | Presbyterian v Davidson Wildcats | L | 35-70 |
| NCAAF | 2021/10/09 17:00 | Morehead State v Presbyterian | L | 38-30 |
| NCAAF | 2021/09/25 17:00 | Presbyterian v Dayton | L | 43-63 |
| NCAAF | 2021/09/18 22:00 | Presbyterian v Campbell | L | 0-72 |
| NCAAF | 2021/09/11 20:00 | Presbyterian v Fort Lauderdale Soaring Eagles | W | 68-3 |
| NCAAF | 2021/09/04 20:00 | Presbyterian v St. Andrews Knights | W | 84-43 |
| NCAAF | 2021/04/17 18:00 | Presbyterian v Drake Bulldogs | W | 28-24 |
| NCAAF | 2021/04/10 15:00 | Davidson Wildcats v Presbyterian | W | 24-29 |