Elon 21-45 James Madison 2021-10-30 18:00
Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Tony Trisciani
Head to Head
| NCAAF | 2021/03/06 18:30 | James Madison v Elon | L | 20-17 |
| NCAAF | 2019/09/28 18:00 | James Madison v Elon | L | 45-10 |
| NCAAF | 2018/10/06 17:30 | Elon v James Madison | W | 27-24 |
| NCAAF | 2017/11/18 18:00 | Elon v James Madison | L | 3-31 |
Home History
| NCAAF | 2021/10/23 17:00 | New Hampshire v Elon | W | 10-24 |
| NCAAF | 2021/10/09 16:00 | Elon v Maine | W | 33-23 |
| NCAAF | 2021/10/02 18:00 | Elon v Richmond | W | 20-7 |
| NCAAF | 2021/09/25 18:00 | William & Mary v Elon | L | 34-31 |
| NCAAF | 2021/09/18 19:30 | Elon v Appalachian St | L | 10-44 |
| NCAAF | 2021/09/11 22:00 | Elon v Campbell | W | 24-23 |
| NCAAF | 2021/09/04 18:00 | Wofford v Elon | L | 24-22 |
| NCAAF | 2021/03/27 20:00 | Elon v Richmond | L | 17-31 |
Away History
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | W | 22-10 |
| NCAAF | 2021/10/16 18:00 | James Madison v Richmond | W | 19-3 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | L | 28-27 |
| NCAAF | 2021/10/02 19:30 | James Madison v New Hampshire | W | 23-21 |
| NCAAF | 2021/09/19 00:00 | James Madison v Weber State | W | 37-24 |
| NCAAF | 2021/09/11 20:00 | Maine v James Madison | W | 7-55 |
| NCAAF | 2021/09/04 22:00 | Morehead State v James Madison | W | 10-68 |
| NCAAF | 2021/05/08 18:30 | James Madison v Sam Houston State | L | 35-38 |