[16] Villanova 28-27 James Madison [5] 2021-10-09 18:00
Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Mark Ferrante
Head to Head
| NCAAF | 2019/10/12 17:30 | Villanova v James Madison | L | 24-38 |
| NCAAF | 2018/10/13 17:00 | James Madison v Villanova | L | 37-0 |
| NCAAF | 2017/10/14 19:30 | James Madison v Villanova | L | 30-8 |
Home History
| NCAAF | 2021/09/25 16:00 | Villanova v Penn State | L | 17-38 |
| NCAAF | 2021/09/18 19:30 | Richmond v Villanova | W | 27-34 |
| NCAAF | 2021/09/11 22:00 | Bucknell v Villanova | W | 3-55 |
| NCAAF | 2021/09/04 16:00 | Villanova v Lehigh | W | 47-3 |
| NCAAF | 2021/04/17 17:00 | Delaware v Villanova | L | 27-20 |
| NCAAF | 2021/04/03 16:00 | Villanova v Maine | W | 44-17 |
| NCAAF | 2021/03/13 18:00 | Rhode Island v Villanova | L | 40-37 |
| NCAAF | 2021/03/06 17:00 | Villanova v Stony Brook | W | 16-13 |
Away History
| NCAAF | 2021/10/02 19:30 | James Madison v New Hampshire | W | 23-21 |
| NCAAF | 2021/09/19 00:00 | James Madison v Weber State | W | 37-24 |
| NCAAF | 2021/09/11 20:00 | Maine v James Madison | W | 7-55 |
| NCAAF | 2021/09/04 22:00 | Morehead State v James Madison | W | 10-68 |
| NCAAF | 2021/05/08 18:30 | James Madison v Sam Houston State | L | 35-38 |
| NCAAF | 2021/05/02 22:00 | North Dakota v James Madison | W | 21-34 |
| NCAAF | 2021/04/24 18:00 | VMI v James Madison | W | 24-31 |
| NCAAF | 2021/04/17 18:00 | Richmond v James Madison | W | 6-23 |