Stadium: Alumni Stadium Round: 1
Home Manager: Rod Milstead Away Manager: Larry Scott
| NCAAF | 2021/04/03 17:00 | Delaware State v Howard | L | 37-28 |
| NCAAF | 2021/02/27 17:00 | Howard v Delaware State | L | 10-17 |
| NCAAF | 2019/09/21 18:00 | Howard v Delaware State | W | 24-9 |
| NCAAF | 2018/10/13 17:00 | Delaware State v Howard | W | 13-55 |
| NCAAF | 2017/10/14 18:00 | Delaware State v Howard | W | 23-52 |
| NCAAF | 2021/10/23 17:00 | Norfolk State v Howard | L | 45-31 |
| NCAAF | 2021/10/09 00:00 | Morgan State v Howard | W | 0-27 |
| NCAAF | 2021/10/02 17:00 | Sacred Heart v Howard | W | 17-22 |
| NCAAF | 2021/09/25 16:00 | Howard v Robert Morris | L | 16-22 |
| NCAAF | 2021/09/18 16:00 | Hampton v Howard | L | 48-32 |
| NCAAF | 2021/09/11 23:30 | Howard v Maryland | L | 0-62 |
| NCAAF | 2021/09/04 18:00 | Howard v Richmond | L | 14-38 |
| NCAAF | 2021/04/03 17:00 | Delaware State v Howard | L | 37-28 |
| NCAAF | 2021/10/23 18:00 | South Carolina State v Delaware State | L | 13-7 |
| NCAAF | 2021/10/09 18:00 | Delaware State v Lynchburg Dragons | W | 56-6 |
| NCAAF | 2021/10/02 21:00 | Delaware State v Wagner | W | 33-27 |
| NCAAF | 2021/09/25 18:00 | Merrimack v Delaware State | L | 47-10 |
| NCAAF | 2021/09/18 23:30 | Delaware State v East Tennessee State | L | 6-38 |
| NCAAF | 2021/09/11 18:00 | Georgetown v Delaware State | L | 20-14 |
| NCAAF | 2021/09/04 20:00 | Delaware State v Bowie State Bulldogs | W | 32-24 |
| NCAAF | 2021/04/17 22:00 | South Carolina State v Delaware State | L | 31-28 |