Stadium: Drake Stadium Round: 1
Home Manager: Todd Stepsis Away Manager: Brian Young
| NCAAF | 2021/10/16 21:00 | Drake Bulldogs v San Diego | L | 10-13 |
| NCAAF | 2021/10/09 17:00 | Dayton v Drake Bulldogs | L | 28-10 |
| NCAAF | 2021/10/02 16:00 | Drake Bulldogs v Butler | W | 6-3 |
| NCAAF | 2021/09/25 17:00 | Valparaiso v Drake Bulldogs | L | 24-21 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | L | 0-38 |
| NCAAF | 2021/09/12 00:00 | Drake Bulldogs v Montana State | L | 7-45 |
| NCAAF | 2021/09/02 23:00 | Drake Bulldogs v W. Virginia Bobcats | W | 45-3 |
| NCAAF | 2021/04/17 18:00 | Presbyterian v Drake Bulldogs | L | 28-24 |
| NCAAF | 2021/10/16 17:00 | St. Thomas (MN) v Stetson Hatters | L | 38-7 |
| NCAAF | 2021/10/09 16:00 | Stetson Hatters v Marist | L | 3-34 |
| NCAAF | 2021/10/02 17:00 | Davidson Wildcats v Stetson Hatters | L | 35-28 |
| NCAAF | 2021/09/25 17:00 | Stetson Hatters v Princeton | L | 0-63 |
| NCAAF | 2021/09/11 22:00 | Stetson Hatters v Ave Maria | W | 49-16 |
| NCAAF | 2021/09/04 22:00 | Stetson Hatters v Warner | W | 54-14 |
| NCAAF | 2021/04/10 20:00 | Stetson Hatters v San Diego | L | 10-34 |
| NCAAF | 2021/04/03 17:00 | Presbyterian v Stetson Hatters | L | 26-3 |